Metformin, a widely used drug for managing type 2 diabetes, has gained significant attention for its potential longevity benefits based on multiple preclinical and clinical studies. The interest in metformin as a longevity agent stems from its role in modulating pathways linked to aging and chronic diseases.
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The mechanisms through which metformin operates are multifaceted, involving modulation of metabolic processes, reduction of inflammation, and potential impacts on cancer biology. One of the primary mechanisms attributed to metformin's effects on longevity is its ability to enhance insulin sensitivity and reduce hyperglycemia. By activating AMP-activated protein kinase (AMPK), metformin promotes cellular energy homeostasis, which is crucial for maintaining metabolic health